Modulation of Polymer/DNA Release from Poly(lactic-co-glycolic acid) Microspheres through Poly(ethylenimine) Modification and Loading Concentration

摘要

These results show that the modification of bPEI with HA and the concentration of loaded polymer/DNA complexes can significantly alter the entrapment and release profiles from PLGA microparticles. The HA in this system most likely accelerated the degradation of the particles resulting in this increased release. This is significant in that it offers insight into the effects of modification of gene delivery vectors on a controlled release system designed to achieve a sustained therapeutic response. Additionally, the zwitterionic nature of the bPEI-HA polymer resulted in increased complex encapsulation in this system. The use of HA drastically altered and arguable improved the overall effectiveness of this system. Understanding these results can result in enhanced delivery of therapeutic DNA from engineered microparticles.