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SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE
SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE
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机译:掺杂二氮杂硅酸酯的聚合物基质与酯基包覆的聚(乳酸-乙醇酸)添加剂的一氧化氮缓释涂层
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摘要
A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
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