Decellularized Skeletal Muscle Extracellular Matrix as an in vitro Model for Intramuscular Drug Development

摘要

We have demonstrated that decellularized skeletal muscle ECM can be used as an in vitro model for interactions between a drug and ECM. Furthermore, we show that the nature of the interaction can be elucidated using compounds that alter binding, and our data indicate that cobinamide is binding to the ECM via the cobalt ion. We are currently studying the specific ECM component to which the binding occurs. This model could allow for improved formulation of drugs intended for IM injection.