Controlled delivery of HB-EGF significantly accelerated wound closure within 17 days by comprehensive healing which included expedited re-epithelialization, improved granulation tissue formation, and angiogenesis. Epithelial cell migratory capacity was improved and proliferative capacity was uninhibited. These results suggest that coacervate-based delivery of HB-EGF may serve as a new therapy for accelerating the healing of cutaneous wounds. Future work includes a diabetic rodent model as well as a porcine model.
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