A novel biomems device for efficient on-chip single cell loading and 3D rotation

摘要

This paper reports a novel bioMEMS device that integrates mechanical constriction for single cell trap in the channels, which are enclosed by thick (or 3D) C-PDMS (carbon-black-PDMS) electrodes and bottom planar transparent electrode for dielectrophoretic (DEP) cell manipulation. Leveraging hydrodynamics and dieletrophoresis, this simple biomedical microsystem enables more efficient loading of one single cell in place and controllable 3D cell rotation than before.