A quantitative evaluation of skin phantom by skin TD-OCT

摘要

Optical Coherence Tomography (OCT) has been practically used in ophthalmology, however, its quantitativeness is more valued for the evaluation of human skin. In this study, Time-Domain typed Optical Coherence Tomography (TD -OCT) was specialized to evaluate human skins quantitatively, and skin phantom measurements were assessed. At first, skin phantoms at different concentrations of titanium dioxide were prepared and measured according to its representation of dermis on human skin. Same increment of the extinction coefficient was obtained as the concentration increases. This OCT measurement result was compared with the result from the transmittance experiment. The difference between two results was considered as the effect of multiple scattering in the strong scattering medium. Next, the TD-OCT measurement was performed on the human skin. Extinction coefficients were evaluated with criterions of accurateness in medical field. Based on the linearity of the specialized TD-OCT, the extinction coefficient obtained by this method could accurately represent optical property of dermis and epidermis of human skin.