Systems Biology through complex networks, signal processing, image analysis, and artificial intelligence

摘要

Comprehensive understanding of biology can only be achieved by integrating several type of data and models across wide time and space scales, ranging from molecules to ecology. While substantial advances have been obtained through the reductionist approach, where specific sybsystems are investigated separately, usually at microscopic scale, the integration of structural and dynamical concepts along several scales holds the key for major breakthroughs. Such endeavours are part of the so-called systems biology area. This article discusses and illustrates how complex networks, image analysis, signal processing and artificial intelligence can be integrated into systems biology research, providing an unprecedented opportunity for scientific and technologic advances. The generality of complex networks for system representation allows this type of structures to be effectively used to model both the architecture and function of virtually any biological entity. At the same time, image analysis paves the way not only for the characterization of phenotipic traits, but also for mapping several geometric biological structures (e.g. neuronal systems, bone canals, cell organelles, etc.) as complex networks. Several concepts and methods from signal processing can then be applied in order to characterize, classify and model the structure and dynamics in such network representations. Artificial intelligence approaches, especially pattern recognition, are also necessary in order to automate, integrate and interprete all such myriad of data and models. In addition to discussing, in a brief though accessible fashion, each of these areas as well as their integration into systems biology, the current work also illustrates the respective potential of this approach with respect to some of the author's recent works.