pH - Responsive Polymeric Nanoparticles Fabricated By Dispersion Polymerization As A Platform For The Delivery Of Anticancer Drugs

摘要

In the present study, pH- resposive nanoparticles were prepared with acetal crosslinkers. Three different acetal crosslinkers were synthesized by reacting a methacrylate monomer with three different benzaldehydes.The formation of acetal crosslinkers was confirmed by nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectroscopy (HR-MS). The hydrolysis studies of the crosslinkers showed that the rate of hydrolysis of the crosslinkers was faster in the acidic pH 5 compared to physiological pH 7.4. These results confirm acid sensitivity of the acetal crosslinkers. Blank nanoparticles were synthesized with acetal crosslinker and characterized in terms of morphology, particle size and zeta potential. Results suggest that these nanoparticles can be used in the fabrication of systems for treatment of cancer.