Understanding the Biological Impact of Nanoengineered Surfaces

摘要

Two model nanoengineered surfaces, a nanopatterned block copoloymer (BCP) film and a polymer nanofiber surface, were utilized to investigate the affect that nanofeatures have on protein adsorption. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to characterize the topography of the surfaces. Protein adsorption was quantified using a bicinchoninic acid (BCA) based assay. Future work will focus on investigating the mechanisms and dynamics of adsorption on surfaces with nanoscale features. This data will provide a better understanding of how these surfaces will react in the body.