A COMPUTATIONAL STUDY OF THE INJECTION THERAPY FOR MYOCARDIAL INFARCTION DURING THE NECROTIC STAGE

摘要

Myocardial infarction is an increasing health problemworldwide. Due to an under-supply of blood, the cardiomyocytesin the affected region permanently lose their abilityto contract. This in turn gradually weakens the overallheart function. A new therapeutic approach based on theinjection of gel into the infarcted area aims to support thehealing and to inhibit adverse remodelling that can lead toheart failure. An accurate computational model is the basisfor obtaining a better understanding of the heart mechanics,in particular, how myocardial infarction and gel injectionsaffect its pumping performance. We are using the inhousecode SESKA which is based on the meshfree movingleast square approximation scheme as a computationalframework. To model the passive mechanical behaviourwe employ a nonlinear transversly isotropic material law.The main focus of this contribution is to show how gel injectionsinfluence the mechanics of the left ventricle duringdiastolic filling and systolic isovolumetric contractionin the necrotic phase.