A 2D model of traveling wave Dielectrophoresis microelectrode array based on printed circuit board technology for manipulation and characterization of malignant and normal liver cells

摘要

the Dielectrophoresis (DEP) is a phenomenon in which a force exists on a particle due to a non-uniform electric field. A widely used technique for particle manipulation and separation is a traveling wave dielectrophoresis (twDEP), where it is particularly applied to biological particles. In this work, a 2D model of traveling wave microelectrode array of printed circuit board (PCB) based technology is presented and discussed. The twDEP is an electro-kinetic technique resulting from the interaction of a non-uniform electric field and polarizable particles. The electric field and the interaction of a nonuniform electric field and polarizable particles were simulated using COMSOL Multiphysics?. The proposed twDEP is used to manipulate liver cells and distinguish between malignant and normal liver cells. In the scope of paper, a concentric ring microelectrodes based on PCB technology are designed for manipulating liver cells, as well distinguishing between malignant and normal liver cells using COMSOL Multiphysics?.