A 2D model of traveling wave Dielectrophoresis microelectrode array based on printed circuit board technology for manipulation and characterization of malignant and normal liver cells

摘要

the Dielectrophoresis (DEP) is a phenomenon in which a force exists on a particle due to a non-uniform electric field. A widely used technique for particle manipulation and separation is a traveling wave dielectrophoresis (twDEP), where it is particularly applied to biological particles. In this work, a 2D model of traveling wave microelectrode array of printed circuit board (PCB) based technology is presented and discussed. The twDEP is an electro-kinetic technique resulting from the interaction of a non-uniform electric field and polarizable particles. The electric field and the interaction of a nonuniform electric field and polarizable particles were simulated using COMSOL Multiphysics®. The proposed twDEP is used to manipulate liver cells and distinguish between malignant and normal liver cells. In the scope of paper, a concentric ring microelectrodes based on PCB technology are designed for manipulating liver cells, as well distinguishing between malignant and normal liver cells using COMSOL Multiphysics®.