4.2 A fully integrated CMOS fluorescence biochip for multiplex polymerase chain-reaction (PCR) processes

摘要

Integration and miniaturization of bio-molecular detection systems into electronic biosensors and lab-on-chip platforms is of great importance. One widely recognized application area for such devices is nucleic acid (DNA and RNA) detection, specifically, nucleic acid amplification testing (NAAT), which relies on enzymatic processes such as polymerase chain reaction (PCR) to increase the copy number of target sequences and detecting them spectroscopically [1,2].