We demonstrate the high potential of redox-sensitive nanogels as vehicles for the targeted delivery of high molecular weight hydrophilic payloads such as proteins by crosslinking of thiol-functional prepolymers in inverse miniemulsion. Relatively high loading levels of proteins were achieved with retention of their activity. Biocompatibility, intracellular degradability, fully synthetic polymeric building blocks with molecular weights that allow renal clearance and the possibility to tailor the synthetic precursors regarding structure and functionality make this system a versatile platform for drug delivery. Current research focuses on the monitoring of cell uptake and kinetics as well as efficiency of intracellular protein release.
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