Surface properties and biocompatibility of titania nanotubes fabricated using different surfactant additives in the electrolyte

摘要

Surfactant plays great role on the geometrical dimensions of TN. The proliferation of the osteoblast cells was improved by the dimensions and topography of the nanotubes with the filopodia of the growing cells going into the nanotube pores, producing an interlocked cell structure. The number of cells adhering to the TN surface was superior to that on the Ti-polished, TN-CTAB and TN-SDS surfaces. The MTT assays and ALP expression revealed pronounced cell proliferation and differentiation on the TN surface compared to the other surfaces. In addition, the higher surface roughness led to better cell attachment and proliferation on the nanotubular titanium surface. Such an array of vertical TN well adherent to a Ti implant surface can be useful as an excellent bioactive surface layer for orthopedic and dental applications because the cell adhesion and bone growth on implant surface can be accelerated.