Mutifunctional magnetic nanoparticles-nuclear targeting peptide complexes

摘要

We have synthesized various magnetic nanoparticles conjugated with protamine which are approved by Food and Drug Administration (FDA) for clinical use and known to associate with protein translocation into cell nuclei. The intemalization of MNPs inside the cells increased greatly after protamine midification. Moreover, the efficacy of intracellular hyperthermia and gene delivery are also significantly enhanced. Our work demonstrates that PR-MNPs will be useful in tumor theranostic as multifunctional regent.