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Thermo-Responsive and Reduction-Sensitive Polymeric Micelles for Intracellular Anticancer Drug delivery

机译:用于细胞内抗癌药物递送的热响应性和还原敏感性聚合物胶束

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摘要

Novel thermo-responsive and reduction-sensitive polymeric micelles for PTX delivery were investigated. This facile non-toxic system showed easy drug-loading process, high drug-loading capacity (up to 35%) and efficiency (EE> 90%), good stability and enhancement of PTX antitumor activity. Thus, these micelles may serve as a promising intracellular anticancer drug delivery to overcome the MDR problem in chemotherapy.
机译:研究了用于PTX传递的新型热响应性和还原敏感性聚合物胶束。这种简便的无毒系统显示出易于载药的过程,高载药量(高达35%)和效率(EE> 90%),良好的稳定性和增强的PTX抗肿瘤活性。因此,这些胶束可以作为有希望的细胞内抗癌药物递送方法来克服化学疗法中的MDR问题。

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