Plasma deposited pHEMA provides active hydroxyl groups on a SiHy substrate for grafting of molecules via CDI immobilization. We have demonstrated that plasma deposition of pHEMA, followed by CDI immobilization treatment with a mock peptide can graft peptide-like molecules onto a SiHy substrate. This process has the potential to reduce inflammation and irritation caused by extended wear of contact lenses through the grafting of appropriate inflammation-controlling peptides onto contact lens materials. We will assess the effectiveness of these peptides using in vitro and in vivo assays.
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