Development of Lab-on-a-Chip for Early Screening of Biomarkers in Alzheimer's Disease

摘要

Here we reported a novel and sensitive enrichment and separation of any PTM proteins after biotin derivatizaiton. This biomedical microdevice, can proceed g amount of proteins for enrichment of a trace level of modified protein, 10~6 fold less than current commercial avidin column, making it highly desired for any limited amount of biological samples requiring avidin affinity enrichment.