Dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA and hydrophobic small molecules co-delivery

摘要

Small interfering RNA (siRNA)-mediated RNA interference (RNAi) has received considerable attention due to its great potential in molecular therapy of intractable and genetic-related human diseases by silencing the target messenger RNA (mRNA). Development of multifunctional vectors for co-delivery of siRNA and other kinds of therapeutic or diagnostic components is of great interest for achieving synergistic output or image monitoring of therapeutic effect. To this end, we developed a set of dual pH-responsive micelleplexes for siRNA and hydrophobic small molecules (paclitaxel, doxorubicin, amphotericin B) co-delivery.