3D scaffolds based on PHBV/hydroxyapatite nanofibers applied in bone tissue engineering

摘要

The growth behavior of MSCs on the PHBV and PHBV/HA nanofibrous scaffolds (random-oriented and aligned) indicated that the MSCs attached and proliferated more favorably on random-oriented PHBV nanofibrous scaffolds without HA. The introduction of HA could induce MSCs to differentiate into osteoblasts. The orientation of nanofibers showed a distinct effect on cell morphology, while had no obvious influence on osteoinduction of MSCs. The in vivo animal tests indicated that PHBV nanofibrous scaffolds containing HA had significant effect on repairing critical bone defects compared with commercial artificial bones.