Engineering of bone using porous calcium phosphate cement and bone marrow stromal cells for maxillary sinus augmentation with simultaneous implant placement in goats

摘要

As demonstrated by sequential triad-color fluorescence labeling, Micro-CT, as well as histological and histomorphometric analyses, the tissue engineered complex of BMSCs and CPC could promote earlier bone formation and mineralization, maximally maintain the height and volume of augmented maxillary sinus. The average bone-implant contact (BIC) value reflecting the osteointegration was significantly higher in that group. Thus, the tissue engineered bone of BMSCs/CPC might be an ideal alternative and superior to autogenous bone or CPC alone for the maxillary sinus floor augmentation and simultaneous implantation. This would be potentially of great significance to achieve early loading of implant to restore the oral function in clinic.