N-acetylgalactosamine Functionalized Mixed-Micelle Nanoparticles for Targeted Delivery of siRNA to the Liver

摘要

In conclusion, a novel GalNAc functionalized MMP, self-assembled from mixture of mPEG_(45)-b-PCL_(29) and PCL_(29)-b-PPEEA_(21) has been developed and their properties can be conveniently manipulated by chaning the polymer ratio. The GalNAc-MMP can deliver siRNA specifically to hepatocytes to knock-down target gene expression.