Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels

摘要

This study was to prepare polycaprolactone (PCL) nanoparticles.The biodegradable PCL was used as the carrier,and Azithromycin (AZM) was used as the model drug.AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method.The effect of preparation condition:concentration of PCL,molecular weight of PCL,organic solvents,dosage ratio and so on,were specially noted and compared.A homogeneous size distribution and good dispersion were observed,the average diameter was around 70～400 nm,and the distribution index was 0.036～0.136.The drug loading reached 27.69 ％,and the efficiency of encapsulation reached as high as 93.25％.The results were better than the other similar researches,this preparation way was successful.