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Logic Programming for Boolean Networks

机译:布尔网络的逻辑编程

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摘要

The Boolean network is a mathematical model of biological systems, and has attracted much attention as a qualitative tool for analyzing the regulatory system. The stable states and dynamics of Boolean networks are characterized by their attrac-tors, whose properties have been analyzed computationally, yet not much work has been done from the viewpoint of logical inference systems. In this paper, we show direct translations of Boolean networks into logic programs, and propose new methods to compute their trajectories and attrac-tors based on inference on such logic programs. In particular, point attractors of both synchronous and asynchronous Boolean networks are characterized as supported models of logic programs so that SAT techniques can be applied to compute them. Investigation of these relationships suggests us to view Boolean networks as logic programs and vice versa.
机译:布尔网络是生物系统的数学模型,作为分析监管系统的定性工具已引起了广泛关注。布尔网络的稳态和动力学以其吸引子为特征,其属性已通过计算进行了分析,但从逻辑推理系统的角度来看,所做的工作并不多。在本文中,我们展示了布尔网络到逻辑程序的直接转换,并提出了基于对此类逻辑程序的推断来计算其轨迹和引诱剂的新方法。特别是,同步和异步布尔网络的点吸引子都被描述为逻辑程序的受支持模型,因此SAT技术可以应用于计算它们。对这些关系的研究建议我们将布尔网络视为逻辑程序,反之亦然。

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