256-site active neural probe and 64-channel responsive cortical stimulator

摘要

The 0.35µm CMOS active probe and stimulator enables responsive neural stimulation of the brain cortex. It monitors extracellular neural activity on 256 sites in the brain and generates 64 event-triggered current-mode neural stimuli. Each 0.035mm² fully differential neural recording channel includes a 8-bit single slope ADC. Each 0.02mm² neural stimulation channel reuses an OTA for both current sampling and current sourcing. The 13.5mW prototype is flip-chip bonded with a 64-shank Utah electrode array and validated in spatial recording of epileptic neural activity in the mouse hippocampus.