Delivery of an anti-cancer drug from a magnetically controlled MEMS device show cytotoxicity in PC3 and HUVEC cells

摘要

We have developed a magnetically controlled MEMS drug delivery device for on-demand release of defined quantities of an anti-cancer drug, docetaxel (DTX). A drug-loaded micro reservoir (Ø6mm×550µm) is sealed by a 40µm-thick elastic magnetic PDMS (polydimethylsiloxane) membrane with a laser-drilled aperture (∼100×100µm²). Discharge of the drug solution and the release rates are controlled by an external magnetic field. Controlled and reproducible release rates of DTX have been achieved for 35 days. We report on the cytotoxicity of the released drug from the device (monitored as cell viability) and show that DTX maintains cytotoxic effects for two months.