Rapid and repeated bolus drug delivery enabled by high efficiency electrochemical bellows actuators

摘要

For the first time, rapid and repeatable delivery of precise drug boluses (up to 40 15-second boluses of 19.12 ± 0.73 µL cocaine within 50 minutes) is achieved with a high efficiency MEMS electrolysis actuator. Gas bubble recombination parameters and drug viscosity were investigated. Nafion^®-coated electrodes provided superior pumping performance (linearity and repeatability) compared to uncoated electrodes.