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Single Neuron Transient Activity Detection by Means of Tomography

机译:层析成像检测单神经元瞬时活动

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Spectral methods allow the estimation of the firing frequency in the activity of a single neuron. However, transient periods, changes in the neuron firing frequency or even changes in the neuron activity regime (rest, tonic firing or spiking) due to different inputs or to the presence of neurotransmitters are not well detected by means of these methods due to the fact that frequency and time are not commutable operators. Some other methods have been developed to deal with local transients, for example the localized Fourier transform or the Wigner distribution. Unfortunately these localized methods need fine tuning to find an adequate working resolution and the resulting coefficients are hard to interpret. In this work we propose the use of the tomographic transforms to detect and characterize transient components in the behaviour of a single neuron.
机译:频谱方法可以估计单个神经元活动中的放电频率。然而,由于以下事实,不能通过这些方法很好地检测到由于不同的输入或存在神经递质而导致的短暂时期,神经元放电频率的变化,甚至神经元活动状态的变化(休息,强直性放电或尖峰)。频率和时间不是可交换的运算符。已经开发了一些其他方法来处理局部瞬变,例如局部傅立叶变换或Wigner分布。不幸的是,这些局部方法需要进行微调以找到合适的工作分辨率,并且所产生的系数难以解释。在这项工作中,我们建议使用断层扫描来检测和表征单个神经元行为中的瞬时成分。

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