Multifunctional Block Copolymer Nanoparticles for Controlled Release of Bone Morphogenetic Protein 2

摘要

We have successfully synthesized amphiphilic diblock and multiblock copolymers capable of organizing into defined micellar structures in aqueous media. A BMP-2/heparin complex was immobilized to the particles through a heparin binding peptide conjugated to the hydrophilic shell of the nanoparticles. Controlled release of BMP-2 was achieved through the interplay of peptide/heparin/BMP-2 interactions. Molecular design of block copolymers with defined architectures and assembly characteristics offers the opportunity to modulate the release of BMP-2 in a spatial and temporal manner.