Decellularized Porcine Brain Matrix as a Cell Culture Platform and Tissue Engineering Scaffold

摘要

Brain tissue is able to be decellularized and still retains extracellular matrix protein components and glycosaminoglycans, which may be used as a cell culture platform as induced pluripotent stem cell-derived neurons are able to grow and mature on the brain matrix. The brain matrix is also able to self-assemble and gel in vivo forming a nanofibrous scaffold demonstrating feasibility as an injectable, brain-specific tissue engineering scaffold.