Nanoscale properties of hydroxyapatite influence osteolytic activity of metastatic breast cancer

摘要

By incorporating hydrothermally aged HA nanoparticles of varying size into polymeric scaffolds, we were able to simulate bone microenvironmental conditions and evaluate how nanoscale HA properties affect bone metastatic breast cancer cell behavior. We found that HA particle size and crystallinity are crucial to regulating tumor growth and expression of IL-8, two key aspects of osteolytic breast cancer metastasis.