The biomimickmg conductive biointertace was built on electropolymerization and synthesis of EDOT-PC and EDOT-MI. With EDOT-PC composition higher than 50%, the EDOT copolymer could be antifouling to both proteins and cells, and become specific binding toward neuron cells after conjugated with IKVAV ligands. The conductive biointerface could sustain long-term cell culture, and the cell-substrate interaction could be well tuned by adjusting comonomer composition to give optimized cell adhesion, proliferation. Micro-pattern fabrication on the EDOT copolymers was further developed, and their potential of applications in biodevices toward electrically stimulating and/or sensing cells was demonstrated.
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