The Impact of Dissolution on Particle Size and Particle Shape of Multi-Component Drug Delivery Systems

摘要

The particle size and particle shape of multi-component controlled release drugs must be considered during their dissolution of as a function of time. Though the size and shape of the particles are well known when the capsules are filled, oftentimes, little is known about the changes in size, shape, and morphology during dissolution. Particles that start as spheres or granules will eventually take new shapes as they break down. Particle Shape analysis is used to show that the multiple components of the drug are similar in size but have distinct shapes as well as to demonstrate that particle shapes change as they dissolve.