Optimization of Ultra High Pressure Preparation Parameters of Ursolic Acid :Cyclodextrin Inclusion Compound by Orthogonal Array Designs

摘要

In order to get the ultra high pressure (UHP) preparation parameters of ursolic acid (UA)cycIodextrin (β-CD) inclusion compound, an orthogonal experiment L9(3)4 was applied to optimize the best preparation conditions. Inclusion pressure, inclusion time, inclusion temperature and ratio of β— CD and UA were the main factors to influence the inclusion ratio of the UHP preparation . The four factors chosen for the present investigation were based on the results of a singlefactor test. The optimum preparation parameters were determined as follows: inclusion pressure 200Mpa, inclusion temperature 25°C, inclusion time 10min, ratio of β-CD and UA . Under optimized conditions, the inclusion ratio was 78.4%. All the results indicated that UHP preparation of UA : β-CD inclusion compound was a suitable method for it has shorter time and higher inclusion ratio.