OEDIPE : A Personalised Internal Dosimetric Tool Associating Voxel- Based Phantoms with Monte Carlo Calculation for Nuclear Medicine

摘要

In nuclear medicine and particularly in internal radiotherapy, one of the major challenges is todetermine the dose for each patient. Current internal dosimetric estimations are based on the Medical InternalRadiation Dose (MIRD) formalism and use standard mathematical models. These standard models are often farfrom a given patient morphology and do not allow to perform patient-specific dosimetry. Therefore, theLaboratory of Internal Dose Assessment of IRSN has developed an innovative software named OEDIPE, Frenchacronym for “tool for personalised internal dose assessment”, in collaboration with the French institute of healthand medical research of Nantes (U892). This software is a user-friendly graphical interface that takes into accountspecific patient parameters. Indeed, it allows the creation of voxel phantoms based on the patient anatomicalimage and directly prepares the MCNPX input file suitable for dose calculations. Radionuclides can be distributedat the organ and voxel scale, using cumulated activities based on tomographic images. Absorbed dose calculationcan also be performed at these scales, in allowing notably the visualisation of superimposed isodose curves andanatomical images. It could also take into account the temporal distribution of radiopharmaceuticals within thebody. OEDIPE has already been validated by comparison either with others codes and with experimental data. Thestudy presented here is a first approach in internal radiotherapy. It deals with a personalised dose calculationcarried out for the treatment of hepatocellular carcinoma. Thus, as a result of its flexibility in accommodatingcomplex geometry, the method developed not only represents a diagnostic tool, but also opens up exciting newpossibilities such as the optimisation of protocols, in nuclear medicine and in particular in targeted radiotherapy.