Smart drug delivery using electrospun hollow nanofibers

摘要

This paper report on a novel nano-electro-mechanical systems (NEMS) technology - nanoscale coaxial soft smart system (nCS³) that enables radial displacements of a multi-layered coaxial hollow fiber (CHF) and controlled modulations of a nanofluidic flow patterns inside the CHF responding to changes in local environments. The nCS³ has a unique nanostructure that consists of a liquid core and multiple layers of polymer and stimuli-responsive hydrogel. Smart and controlled release of drug molecules is realized using the nCS³.