SYNTHESIS, MECHANICAL AND BONE CELL MATERIALS INTERACTION STUDIES ON SRO AND MGO DOPED RESORBABLE TRICALCIUM PHOSPHATE FOR BONE TISSUE ENGINEERING

摘要

Calcium phosphates are of significant interest due to their chemical similarity with the inorganic component of natural bone. We have used different dopants, such as Sr~(2+) Mg~(2+), Si~(2+), and Zn~(2+) to study the effects of dopant chemistry on resorbability and strength loss behavior of TCP. Dopants were introduced in TCP both by chemical synthesis and physical mixing methods with an amount of <5wt% of TCP amount. For example, addition of binary dopant composition, such as Mg~(2+) and Sr~(2+), improved compression strength of TCP from 56.71 MPa to 107.34 MPa. Human osteoblast cell culture was used to determine the influence of dopants on cell-materials interactions, e.g. cell proliferation by MTT. Osteoblast culture studies indicated that the presence of dopant favored cell growth. Our study on both in vitro and in vivo resorption behavior of these doped TCP show as a promising material for bone tissue engineering.