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Mathematical physiological modeling of the relation between local field potentials and spikes recorded inside the subthalamic nucleus

机译:丘脑底核内记录的局部场电势与峰值之间关系的数学生理建模

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During the last decade, the subthalamic nucleus (STN) has drawn the attention of clinicians and researchers becoming the main target for high-frequency deep brain stimulation of the basal ganglia in patients suffering from movement disorders such as dystonia or Parkinson's disease. Currently, a great effort is made both in Medicine and Neurosciences for understanding and modeling in details how the STN cells work. The aim of this work is the development of a phenomenological model of an STN neuron that receives the local field potentials as its input and outputs a spike train. The model is physiologically inspired by the temporal summation observed in neurons. After estimating the model's numerical parameters and stochastic properties by fitting the available intranuclear data, we show that the model can predict with reasonable accuracy single spikes as well as the presence of bursts by following closely the recorded spiking rhythm.
机译:在过去的十年中,丘脑底核(STN)引起了临床医生和研究人员的注意,成为对患有运动障碍(例如肌张力障碍或帕金森氏病)的患者进行高频深脑刺激基底神经节的主要目标。当前,在医学和神经科学领域都做出了巨大的努力,以详细了解和建模STN细胞的工作方式。这项工作的目的是开发一种STN神经元的现象学模型,该模型接收局部场电势作为其输入并输出尖峰序列。该模型受到神经元中观察到的时间求和的生理启发。通过拟合可用的核内数据估算模型的数值参数和随机属性后,我们表明,通过密切遵循记录的尖峰节奏,该模型可以以合理的精度预测单个尖峰以及爆发的存在。

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