Preparation and evaluation of amorphous cefdinir solid dispersions

摘要

Amorphous solid dispersion of cefdinir was developedto improve its solubility and stability. Super-saturationscreening study of binary solid dispersions was performedto find proper additives of enhancing the solubility.Among the chosen additives, stability study wasperformed in solution and solid state, and the ratio of drugand additives were optimized by further study. Ternarysolid dispersions were prepared by mixing vitamin ETPGSand d-mannitol which had stabilizing effect ofamorphous form in binary solid dispersions. Ternary soliddispersion maintained its amorphous form for 75 days ofstability study at 40°C, 75% and its solubility wasimproved. Therefore, this solid dispersion formulationmight be the alternative promising candidate for cefdinir.