SOLID DISPERSION OF CEFDINIR AND PREPARATION METHOD THEREOF

摘要

PURPOSE: amorphous cefdinir solid dispersions and manufacturing method are provided to ensure that thermodynamic (al) stability and good dissolubility. ;CONSTITUTION: amorphous cefdinir solid dispersions contain Cefdinir and sugar alcohol. Sugar alcohol is maltitol, sorbierite, erythrite, lactitol, inositol, mannitol, ribitol, galactitol, xylitoll, maltotritol. The solid dispersions comprise in addition pharmaceutically acceptable additive. A kind of manufacture amorphous cefdinir solid dispersions include: that step Cefdinir monohydrate is dissolved in organic solvent; In the solution that dispersion steps sugar alcohol is prepared; With a step, removes organic solvent and form solvent. ;The 2010 of copyright KIPO submissions