Preparation and Biological Characteristics of Tauroursodeoxycholic Acid (TUDCA) Derivat Derivatized izedExendin Exendin-4

机译：牛磺去氧胆酸（TUDCA）衍生化的Exendin Exendin-4的制备及其生物学特性

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To develop effective antidiabetic exendin exendin-4derivatives, Tauroursodeoxycholic Acid (TUDCA)modified exendin exendin-4s ( TUDCA TUDCA-Ex Ex-4s) were synthesizedand its biological activities were examined. The TUDCA TUDCA-Ex Ex-4s show typical characteristics of GLP GLP-1 receptoragonist and result increased cell survival in ER ER-stressmediated cell death assay.

机译：开发有效的抗糖尿病exendin exendin-4 衍生物，牛磺去氧胆酸（TUDCA）合成了改良的exendin exendin-4s（TUDCA TUDCA-Ex Ex-4s）并对其生物学活性进行了研究。 TUDCA TUDCA- Ex Ex-4s显示GLP GLP-1受体的典型特征激动剂并导致内质网应激细胞存活率增加介导的细胞死亡测定。

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《Annual meeting exposition of the Controlled Release Society》|2009年|p.1-2|共2页
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Sohee Son; Su Young C Chae; Dong-Gyu Jo; Jae Hyung Park; A-Ryeong Gwon; Kang Choon Lee;
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中图分类药学;诊断学;
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机译：牛磺去氧胆酸（THDCA）和牛磺去氧胆酸（TUDCA）在HepG2细胞系中的比较细胞毒性和细胞保护作用。
2. Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line [J] . Francesca Carubbi, Maria Eugenia Guicciardi, Mauro Concari, Biochimica et Biophysica Acta. Molecular and cell biology of Lipids . 2002,第1期

机译：牛磺去氧胆酸（THDCA）和牛磺去氧胆酸（TUDCA）在HepG2细胞系中的比较细胞毒性和细胞保护作用
3. Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. [J] . Carubbi F, Guicciardi ME, Concari M, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2002,第1期

机译：牛磺去氧胆酸（THDCA）和牛磺去氧胆酸（TUDCA）在HepG2细胞系中的比较细胞毒性和细胞保护作用。
4. Preparation and Biological Characteristics of Tauroursodeoxycholic Acid (TUDCA) Derivat Derivatized ized Exendin Exendin-4 [C] . Annual meeting exposition of the Controlled Release Society . 2009

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Preparation and Biological Characteristics of Tauroursodeoxycholic Acid (TUDCA) Derivat Derivatized izedExendin Exendin-4

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