Novel Amphiphilic Copolymers Based on Polyaspartamide Graft with Squalene Residues toObtain Micelles as Colloidal Drug Carriers

摘要

The synthesis and the characterization of two novelamphiphilic copolymers with hydrophilic portions such asan ,on-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA)derivative and hydrophobic portions such as squalenederivatives are reported. These copolymers, able to formself-assembling micelles in aqueous medium, werecharacterized in terms of mean size, zeta potential andCritical Aggregation Concentration (CAC).