Specific Targeting of Cancer Cells with Doxorubicin-Loaded Nanoparticles

摘要

In the present study target-oriented nanoparticlesbased on biodegradable human serum albumin (HAS)loaded with the cytostatic drug doxorubicin were tested.Trastuzumab was covalently linked onto the surface of thenanoparticles. HER2 overexpressing breast cancer cellsshowed a good cellular binding and uptake of thesenanoparticles. The specific transport of the cytostatic drugdoxorubicin with the nanoparticle formulation into theHER2 overexpressing breast cancer cells, their releaseand biological activity was demonstrated.