The unique cellular associations of polyanhydnde nanospheres are a function of the distinct physical and chemical properties of the particles. We observed that the trend of increased nano-sphere interaction with THP-1 human monocytes was based primarily on particle hydrophobic-ity. This phenomenon followed the same trend observed in recently published work using poly (CPH-co-sebacic acid) copolymer nanospheres (38). Together, this research highlights the importance of polymer chemistry in designing polyanhydride nanosphere based vaccine and drug delivery vehicles.
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