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Boosting Kernel Discriminant Analysis and Its Application to Tissue Classification of Gene Expression Data

机译:Boosting核判别分析及其在基因表达数据组织分类中的应用

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Kernel discriminant analysis (KDA) is one of the most effective nonlinear techniques for dimensionality reduction and feature extraction. It can be applied to a wide range of applications involving high-dimensional data, including images, gene expressions, and text data. This paper develops a new algorithm to further improve the overall performance of KDA by effectively integrating the boosting and KDA techniques. The proposed method, called boosting kernel discriminant analysis (BKDA), possesses several appealing properties. First, like all kernel methods, it handles nonlinearity in a disciplined manner that is also computationally attractive; second, by introducing pairwise class discriminant information into the discriminant criterion and simultaneously employing boosting to robustly adjust the information, it further improves the classification accuracy; third, by calculating the significant discriminant information in the null space of the within-class scatter operator, it also effectively deals with the small sample size problem which is widely encountered in real-world applications for KDA; fourth, by taking advantage of the boosting and KDA techniques, it constitutes a strong ensemble-based KDA framework. Experimental results on gene expression data demonstrate the promising performance of the proposed methodology.
机译:核判别分析(KDA)是用于降维和特征提取的最有效的非线性技术之一。它可以应用于涉及图像,基因表达和文本数据等高维数据的广泛应用。本文开发了一种新算法,通过有效地集成Boosting和KDA技术来进一步提高KDA的整体性能。所提出的方法称为增强核判别分析(BKDA),具有多种吸引人的特性。首先,像所有内核方法一样,它以有规律的方式处理非线性,这在计算上也很有吸引力。第二,通过将成对的类判别信息引入判别准则,同时采用boosting来稳健地调整信息,进一步提高了分类的准确性。第三,通过计算类内散点算子的零空间中的重要判别信息,它还可以有效地解决在KDA的实际应用中广泛遇到的小样本量问题。第四,通过利用Boosting和KDA技术,它构成了一个强大的基于集合的KDA框架。基因表达数据的实验结果证明了所提出方法的有希望的性能。

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