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The Influence of Solvent System on the Performance of Polyvinyl Acetate Phthalate (PVAP) Delayed ReleaseCoating Systems

机译:溶剂体系对聚醋酸乙烯邻苯二甲酸酯(PVAP)延迟释放包衣系统性能的影响

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摘要

Polyvinyl acetate phthalate (PVAP) or a fully-formulated delayed release coating system based on PVAP were dispersed in different solvents. Dispersion properties and coated tablet delayed release performance were evaluated. The neat polymer and formulated system yielded physically stable dispersions while the formulated system provided acceptable enteric protection and tablet disintegration.
机译:聚邻苯二甲酸乙酸乙烯酯(PVAP)或基于PVAP的完全配制的延迟释放包衣系统分散在不同的溶剂中。评估了分散性能和包衣片剂的延迟释放性能。纯净的聚合物和配制的体系可产生物理稳定的分散体,而配制的体系可提供可接受的肠溶保护和片剂崩解作用。

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