Hydrodynamic Robustness of Hypromellose and Hydroxypropyl Cellulose Based Modified ReleaseMatrix Systems

摘要

Factors impacting the "hydrodynamic robustness" of hypromellose and hydroxypropylcellulose matrix systems were investigated using the USP III reciprocating apparatus. Drug release from systems with low (10%) polymer level, low drug solubility or erosion dependent release mechanisms were generally found to vary significantly with change in hydrodynamics.