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Long-Circulating Poly(Ethylene Glycol)-Coated Emulsions to Target Solid Tumors

机译:长循环聚(乙二醇)包被的乳剂靶向目标实体瘤。

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Oil-in-water emulsions were prepared with phospholipid or sphingolipid emulsifiers in combination with polysorbate 80 (PS-80) and various poty(ethylene glycol) (PEG) lipid derivatives. The emulsions were evaluated in mice bearing either B16 or C26 tumors. Results showed that PEGylation increased circulation time but accumulation was only observed in the C26 model.
机译:用磷脂或鞘脂乳化剂与聚山梨酯80(PS-80)和各种低级(乙二醇)(PEG)脂质衍生物结合制备水包油乳液。在患有B16或C26肿瘤的小鼠中评估乳剂。结果表明,聚乙二醇化增加了循环时间,但仅在C26模型中观察到了积累。

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