Prostate Cancer-Specific mAb 5D4 Significantly Enhances the Cytotoxicity of Doxorubicin-Loaded Liposomes Against Target Cells In Vitro

摘要

Long-circulating liposomes loaded with doxorubicin (Dox) were addionally modified with prostate cell-specific monoclonal 5D4 antibody. Resultant Dox-loaded 5D4-liposomes specifically recognized prostrate cancer cell lines of several different types and dramatically enhanced cytotoxicity compared to non-targeted Dox-liposomes in vitro while no increased toxicity was observed towards non-prostate (lung) cancer cell line.